Bone Marrow Transplantation

Bone marrow constantly produces stem cells, which in-turn will develop into the type of cells the body needs. Bone marrow transplant (BMT) also called as ‘Stem cell transplant’, is a procedure where-in healthy blood forming stem cells are infused into the body to replace a bone marrow which is not producing enough healthy blood cells. These haemopoietic stem cells in-turn give rise to WBCs, RBCs or Platelets as per need.

We treat a variety of blood-related diseases (both cancerous and non-cancerous) including acute and chronic leukemias, lymphomas and myelomas. Even benign blood disorders like aplastic anemia, thalassemia, sickle cell anemia and other conditions which originate due to the failure of bone marrow , as well as some solid neoplastic diseases, genetic conditions and immune system disorders of varying aetiology.

Each patient’s needs are evaluated and a customized treatment plan is developed, which enables their road to recovery.

Both the cancer and healthy cells in the bone marrow, where blood is formed, are rendered inactive or killed by administering high doses of chemotherapy, radiation, or both. Subsequently, the patient receives new blood-forming cells through an infusion which triggers healthy blood cell development.

Healthy blood cells to treat blood disorders

Bone Marrow Transplant

The blood cells may be sourced either from the blood or bone marrow. There are two types of BMTs:

i)Autologous transplant – Here the patient’s blood cells are collected and stored before initiation of high-dose chemotherapy. Post-treatment these cells are transfused back to the same person. This type of transplant is a rescue operation, as high doses of chemotherapy or radiation are known to damage the bone marrow beyond its regenerative capacity. Such re-transfused blood cells tend to repair the damaged bone marrow.

ii)Allogeneic transplant – In this scenario, blood cells are collected from a donor. This donor may be a member of the family like a sibling or someone unrelated. In this type of transplant, the bone marrow is replaced with healthy marrow from another person whose HLA typing matches ≥ 50% when compared with the patient.

In patients who are unlikely to tolerate high dose chemotherapy, a reduced version of allogenic BMT called mini-transplant is done. Here, much lower doses of chemotherapy is given and the cure of cancer depends on immune destruction of the cancer cells by the donor cells.

Types of BMT done at Sammprada:

Autologous (self-transplant)
Allogeneic (donor transplant)
Haplo identical transplantation
Mini-transplantation
Bloodless transfusion

The blood cells may be sourced either from the blood or bone marrow. There are two types of BMTs:

. The blood cells may be sourced either from the blood or bone marrow. There are two types of BMTs:

Autologous transplant

Here the patient’s blood cells are collected and stored before initiation of high-dose chemotherapy. Post-treatment these cells are transfused back to the same person. This type of transplant is a rescue operation, as high doses of chemotherapy or radiation are known to damage the bone marrow beyond its regenerative capacity. Such re-transfused blood cells tend to repair the damaged bone marrow.

Allogeneic transplant

In this scenario, blood cells are collected from a donor. This donor may be a member of the family like a sibling or someone unrelated. In this type of transplant, the bone marrow is replaced with healthy marrow from another person whose HLA typing matches ≥ 50% when compared with the patient.

. The blood cells may be sourced either from the blood or bone marrow. There are two types of BMTs:

Healthy blood cells to treat blood disorders

Bone Marrow Transplantation

Healthy blood cells to treat blood disorders

Bone Marrow Transplant

Autologous transplant

Allogeneic transplant

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